Welcome to the COBRA research study!




UHN researchers have now closed recruitment for the COBRA study evaluating the modified BCG vaccine for reducing risk and severity of COVID-19


We would like to thank everyone for their participation/continued participation in the study. As we undergo analysis, any publications that arise from our research will be published on our website.

Principal Investigator: Dr. Alexandre Zlotta

The study recruited

Individuals whose professions place them at higher risk of contracting COVID-19, including:

  • Members of police forces
  • Emergency medical services
  • Firefighters
  • Employees of public transport agencies
  • Health service workers
  • Food manufacturing employees

Participants were asked to perform the following activities: 

  • In-person visit at one of the study sites in East, Central, or West GTA
  • Vaccination with modified BCG vaccine (VPM1002) or placebo
  • Collection of a blood sample (15 mL)
  • Biweekly completion of an online questionnaire (4 questions)
  • Second blood draw (another 15 mL) at 7 months

While the study is closed, more details can be found at Additional Information, by email at COVIDBCGSTUDY@UHN.CA or by calling the COBRA HOTLINE at 416-946-4501 EXT. 7510